Radioprotective Effects of GANRA-5 to X-rays and <SUP>12</SUP>C<SUP>6+</SUP>

JIANG Lin; PEI Hailong; ZHU Mingyue; LIU Tingting; XU Dan; SUN Fang; ZHANG Xurui; DING Nan; HU Wentao; WANG Jufang; ZHOU Guangming

doi:10.11804/NuclPhysRev.31.03.423

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. DOI: 10.11804/NuclPhysRev.31.03.423

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Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

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The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and ¹²C⁶⁺ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.

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Radioprotective Effects of GANRA-5 to X-rays and 12C6+

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Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺