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ZHOU Xin, WANG Zhen-hua, ZHANG Hong. Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations[J]. Nuclear Physics Review, 2012, 29(4): 399-405. DOI: 10.11804/NuclPhysRev.29.04.399
Citation: ZHOU Xin, WANG Zhen-hua, ZHANG Hong. Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations[J]. Nuclear Physics Review, 2012, 29(4): 399-405. DOI: 10.11804/NuclPhysRev.29.04.399
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Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations

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  • Current advance in ionizing radiationinduced mitochondrial DNA damage and mutations is reviewed， in addition with the essential differences between mtDNA and nDNA damage and mutations. To extent the knowledge about radiation induced mitochondrial alterations， the researchers in Institute of Modern Physics， Chinese Academy of Sciences developed some technics such as realtime PCR， longPCR for accurate quantification of radiation induced damage and mutations， and indepth investigation about the functional changes of mitochondria based on mtDNA damage and mutations were also carried out. In conclusion， the important role of mitochondrial study in radiation biology is underlined， and further study on mitochondrial study associated with late effect and metabolism changes in radiation biology is pointed out.
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