History and Current Status of PET Devolopment based on Time of Flight
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Graphical Abstract
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Abstract
The principle of time of flight (TOF) positron emission tomography (PET) and a brief review of the history of TOF-PET are introduced. The factors influencing the time resolution of a TOF-PET scanner are presented, especially focus on the intrinsic properties of scintillators and frontend electronics. Challenges and achievements of the structure of data organization and image reconstruction are reviewed. Finally, the benefits of TOF-PET on image quality improvement and tumor detection are emphasized.
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