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Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. DOI: 10.11804/NuclPhysRev.27.02.202
Citation: Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. DOI: 10.11804/NuclPhysRev.27.02.202
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A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

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  • It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study，action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.
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