99mTc Labeling of Carbon Nanomaterials
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Graphical Abstract
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Abstract
The effects of experimental conditions on preparation of 99mTclabeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium， the radiochemical purity of the labeling compounds kept (86±4)% within 2.5 h. The 99mTc labeled multiwalled carbon nanotubes (MWNTs) and nanocarbon blackes (NCBs) obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.
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