Progress in hprt Mutation Assay and Its Application in Radiation Biology
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Graphical Abstract
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Abstract
hprt gene is an Xlinked locus that has been well studied and widely used as a biomarker in mutation detection. hprt mutation assay is a gene mutation test system in mammalian cells in vitro which has been used as a biological dosimeter. In this paper， the biological characteristics of hprt gene， hprt mutation detection methodology and the application of hprt mutation assay in radiation biology are comprehensively reviewed.
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