A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

LI Wen-jian; ZHOU Guang-ming; WEI Zeng-quan; WANG Ju-fang; LI Qiang; DANG Bing-rong; XIE Hong-mei

doi:10.11804/NuclPhysRev.20.01.042

LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. DOI: 10.11804/NuclPhysRev.20.01.042

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A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

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Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...

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A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

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