Abstract: High flux reactors, owing to their high neutron flux, strong irradiation capabilities, and versatile functional applications, can be used to produce a wide range of radioactive isotopes, including scarce nuclides, medical isotopes, and industrial isotopes. The design of irradiation targets plays a vital role in isotope production using high flux reactors, as it significantly impacts isotope yield, production efficiency, and overall reactor safety. Given the diverse physical characteristics of isotope generation, along with differences in reactor configuration and operational conditions, irradiation strategies and target designs vary considerably across isotope types. To ensure high-efficiency isotope production in high flux reactors, it is essential to perform detailed design optimization of target parameters, including material composition, geometric configuration, and irradiation mode, so as to develop an optimized target design scheme. This study investigates the irradiation methods and target design approaches adopted in major high flux reactors both domestically and internationally, and analyzes key technical challenges in the design of irradiation targets for isotope production, with the aim of providing technical references and design insights for the development of advanced isotope target systems in high flux reactor environments.