Abstract: The disposal of depleted fuel is one of the bottlenecks in the sustainable development of nuclear power all over the world. The Accelerator Driven Subcritical System (ADS) is an excellent choice for transmuting nuclear waste. Compared to fast neutron reactors, ADS has a harder energy spectrum and higher MA loading. In order to deal with High Level radioactive Waste (HLW) and to study the transmutation of minor actinides, we transmuted CERCER fuel for 2000 days using a 100-megawatt transmutation reactor. We use the code FLUKA to simulate the spallation reaction between the proton and the target material. The neutron transport and nuclides burnup coupling code IMPC- Burnup 2.0 is used to simulate the transmutation of MA. The results show that the direct fission rate is about 11.26%, which plays an effective role in transmuting MA nuclides in the reactor.