放射性束辐照生物学效应及相关生物物理机理
Biological Effect Induced by Radioactive Ion Beam and Corresponding Biophysical Mechanisms
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摘要: 介绍了β缓发粒子衰变放射性束 9C辐照处于不同贯穿深度上人类唾液腺细胞的深度存活效应。 与稳定的 12C束流相比， 放射性 9C束流在其Bragg峰区附近展示了增强的生物学效应， 即细胞的致死效率明显增强。 探讨了放射性束 9C在其Bragg峰区展示增强生物学效应的生物物理机制， 并介绍了利用另一种放射性束 8B进行辐照生物学效应研究的新进展。 最后， 提出了一些利用放射性束可进行的辐照生物学效应前沿研究。 The depthsurvival effect of a βdelayed particle decay 9C beam on human salivary gland (HSG) cells is presented in this paper. Compared with a stable 12Cion beam， the radioactive 9Cion beam showed an enhanced biological effect， i.e.， remarkably enhanced efficiency in cell killing， at the penetration depths around its Bragg peak. The biophysical mechanisms underlying the enhanced biological effect are discussed herein， and the latest progress in biological effect induced by another radioactive 8Bion beam is introduced. In the end of this paper， several topics concerning the frontier of the radiationinduced biological effects using radioactive ion beams are proposed.
Abstract: The depthsurvival effect of a βdelayed particle decay 9C beam on human salivary gland (HSG) cells is presented in this paper. Compared with a stable 12Cion beam， the radioactive 9Cion beam showed an enhanced biological effect， i.e.， remarkably enhanced efficiency in cell killing， at the penetration depths around its Bragg peak. The biophysical mechanisms underlying the enhanced biological effect are discussed herein， and the latest progress in biological effect induced by another radioactive 8Bion beam is introduced. In the end of this paper， several topics concerning the frontier of the radiationinduced biological effects using radioactive ion beams are proposed.
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