Abstract: With rapid advancements in physics and particle medicine, the domestic accelerator industry has grown rapidly. During the 12th Five-Year Plan period, the Institute of Modern Physics of the Chinese Academy of Sciences took on a plurality of accelerator projects. Nevertheless, the stability of the coupler, a crucial system within the cavities of accelerators, has encountered certain difficulties. The alumina ceramics, which constitute the core component of the coupler, are increasingly prone to breakage and solder joint failures due to their inferior environmental adaptability, inadequate mechanical properties, and high gas emissions. Conversely, with the advancements in medical technology and materials science, zirconia ceramics have emerged as a prospective remedy for these problems. This type of ceramic is highly esteemed for its outstanding environmental adaptability, remarkable mechanical properties, and excellent high-temperature resistance, exhibiting extraordinary value in dental applications. This study investigates the use of zirconia ceramics in a 162.5 MHz 3-1/8" standard ceramic window, combining experimental data with finite element RF simulations and multi-physics analysis. A new coupler featuring a zirconia ceramic window was tested on a Quarter-Wave Resonator, demonstrating excellent alignment between electromagnetic simulations and measurement results. This reveals the substantial application potential and practical worth of the zirconia ceramic material in the context of accelerators.